Research on 3D microstructure resolution of femtosecond laser two-photon polymerized hydrogels at RIKEN has made new progress

2023-06-09

Hydrogels have physical and chemical properties similar to extracellular matrix, good mechanical properties, self-healing ability and responsiveness, and can be used to construct micro-nanomimetic structures for tissue regeneration, and provide micron-scale surface morphology to regulate cell behavior, such as cell adhesion, migration or the release of survival, proliferation and differentiation factors. Therefore, hydrogels are widely used in fields such as tissue engineering and drug delivery. However, the preparation of high-precision three-dimensional (3D) arbitrary biocompatible hydrogel scaffolds remains a challenge. In order to adapt to future developments in the biomedical field, it is imperative to develop new hydrogel materials with fine 3D geometry.

Recently, A team of researcher Zheng Meiling from the Laboratory of Organic Nanophotonics at the Biomimetic Intelligent Interface Science Center of the Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences published a paper titled "22 nm Resolution Achieved by" at ACS Applied Materials & Interfaces Femtosecond Laser Two-Photon Polymerization of a Hyaluronic Acid Vinyl Ester Hydrogel” (DOI: 10.1021/acsami.3c04346), proposing a novel strategy for the regulation of single cells with true 3D highly detailed arbitrary designable topologies.

The first author of the paper is Duan Qi, a graduate student of the class of 2021, and the corresponding author is Zheng Meiling, a researcher. 

This article is reproduced author: Laser Manufacturing network Source: Institute of Physics and Chemistry, Chinese Academy of Sciences